Most clients come to the clinic focused on a mechanical problem: a stiff neck, a misaligned back, or a tight hip. What often goes overlooked is the underlying systemic chaos caused by hormonal imbalances. Hormones are the body’s chemical messengers, and when they are out of sync—whether due to chronic stress, age, or metabolic factors—they drive widespread inflammation and amplify pain signals. Understanding the influence of hormones like cortisol, estrogen, and testosterone is essential because they affect much of what we treat: muscle stiffness, joint wear, nerve sensitivity, and overall tissue repair.
1. What are hormones? The body's chemical messengers
Hormones are signaling molecules produced by the endocrine system (glands like the adrenals, thyroid, and ovaries). They travel through the bloodstream to regulate virtually every process, from metabolism and sleep to immunity and pain response.
Hormones operate via a delicate feedback loop. If your brain perceives a threat, your adrenal glands release stress hormones. If hormone levels are too high or too low for too long, the system breaks down, leading to the chronic musculoskeletal symptoms that bring you to our clinic.
2. The universal link: cortisol, stress, and muscle guarding
The stress hormone cortisol is the primary driver of the hormone-pain connection across all genders and age groups.
Systemic inflammation: While cortisol is necessary for survival, chronic high cortisol (due to ongoing stress) leads to systemic inflammation. This makes tissues and joints more reactive, accelerates degeneration, and reduces the effectiveness of anti-inflammatory efforts.
Chronic muscle guarding: High cortisol promotes the "fight or flight" response. This translates directly to chronic muscle guarding, where muscles in the neck, shoulders, and low back remain tense even at rest. This guarding is the underlying cause of many spasms and persistent stiffness that require therapeutic massage and chiropractic adjustment.
Tissue repair: Prolonged cortisol exposure slows down the tissue repair process, meaning injuries, muscle strains, and post-treatment soreness take longer to resolve.
3. Estrogen, menopause, and musculoskeletal pain
The hormonal shifts experienced by women, particularly during perimenopause and menopause when estrogen declines, have a profound and direct impact on musculoskeletal health.
Collagen and fascia loss
Estrogen helps maintain collagen, the structural protein in fascia and tendons. Its loss leads to stiffer, less elastic fascia and reduced tissue mobility.
Increases muscle tightness, reduces range of motion, and makes tissue harder to release via massage and stretching.
Bone density changes
Estrogen protects bone density by slowing bone breakdown. Declining levels lead to accelerated bone loss and increased risk of osteoporosis.
Increased fragility necessitates tailored adjustments and affects posture and stability.
Pain sensitivity
Estrogen modulates the activity of pain receptors in the nervous system. Lower levels can directly decrease pain tolerance and increase joint sensitivity throughout the body.
Can make clients feel more sensitive to deep tissue work and amplify minor joint pain.
4. Testosterone and thyroid
While estrogen is a major player, other hormones also dictate musculoskeletal health for everyone:
Testosterone (all genders): Essential for maintaining muscle mass and density. Declining testosterone (common in aging men and women) leads to sarcopenia (muscle wasting) and weakness, forcing the smaller muscles of the spine to compensate, increasing back pain risk.
Thyroid hormones: Hypothyroidism (low thyroid function) can slow metabolism, leading to fatigue, muscle cramps, joint aches, and chronic muscle pain, mimicking the symptoms of arthritis or fibromyalgia.
5. The holistic solution
At Parkside Clinic, our treatments are designed to manage the physical symptoms of hormonal imbalance and encourage systemic balance:
Chiropractic adjustments: Correcting alignment restores optimal biomechanics, relieving the mechanical stress on joints already made sensitive by inflammation.
Massage therapy: Directly releases the chronic muscle guarding driven by high cortisol and improves circulation and elasticity in the fascia.
Acupuncture: Highly effective for supporting the endocrine system and stress response. Specific points can help regulate the hypothalamic-pituitary-adrenal (HPA) axis, improving the body's ability to manage cortisol and systemic inflammation.
Movement for clearance: Consistent, gentle movement, such as rebounding or brisk walking, is vital for managing inflammation, as it aids in the lymphatic drainage that helps clear metabolic and hormonal waste products from the tissues (a topic we explored in detail in The Lymphatic System: The Body's Silent River).
If you suspect your pain is linked to chronic stress or hormonal shifts, consult with your primary care provider for hormone testing to complement your physical treatments.
January in Portland
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Image: Portland’s Folk Festival
Come visit us at Parkside
Come see our expert team at Parkside Clinic where we tailor our care to your specific condition and tap into your body’s natural healing ability. Make an appointment, or if you have any questions, contact us.

